Munenori Takehara, Hideo Hirohara (auth.), Yoshimitsu Hamano's Amino-Acid Homopolymers Occurring in Nature PDF

By Munenori Takehara, Hideo Hirohara (auth.), Yoshimitsu Hamano (eds.)

ISBN-10: 3642124526

ISBN-13: 9783642124525

Microorganisms are able to generating a wide selection of biopolymers. Homopolymer peptides, that are made from just a unmarried kind of amino acid, are some distance much less ubiquitous. the single amino-acid homopolymers recognized to take place in nature are offered during this quantity. Poly-epsilon-L-lysine is a polycationic peptide and shows antimicrobial task opposed to a large spectrum of microorganisms. it's either secure and biodegradable and is hence used as a nutrition preservative in different nations. furthermore, there was nice curiosity in clinical and different functions of poly-lysine and its derivatives. against this, poly-gamma-glutamic acid is an strange anionic polypeptide. it's also water soluble, biodegradable, fit for human consumption, non-toxic and non-immunogenic and will be chemically changed to introduce a variety of medicinal drugs. those positive factors are very worthy for pharmaceutical and biomedical purposes. Poly-glutamic acid can be a hugely beautiful as meals ingredient.

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Extra info for Amino-Acid Homopolymers Occurring in Nature

Example text

3 Cloning of the Gene Encoding Pls . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Catalytic Mechanism of Pls . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Substrate Specificity of Pls . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 4 Concluding Remarks and Future Perspectives . . . . . . . . . . . . . . . . . . . . . . . 38 References . . . . . . . .

Shima and coworkers investigated the relationship between the molecular size of e-PL and its antimicrobial activity against Escherichia coli K-12 (Shima et al. 1984). e-PL with more than nine L-lysine residues severely inhibited microbial growth; however, the L-lysine octamer demonstrated negligible antimicrobial activity. In contrast, chemically synthesized a-poly-L-lysine that contains a considerably longer chain of L-lysine residues (50 residues), which show linkages between the a-carboxyl and a-amino groups, demonstrates a lower activity than e-PL.

58 Abstract Poly-e-L-lysine (e-poly-L-lysine, e-PL) is used as a food additive on the basis of its strong antimicrobial activity (Fine chem 29:18–25, 2000). e-PL is industrially produced by fermentation process using Streptomyces albulus. Recently, the biosynthetic mechanism (Nat Chem Biol 4:766–772, 2008) and microbial degradation of e-PL (FEMS Microbiol Lett 207:147–151, 2002; Arch Microbiol 178:325–330, 2002; J Biosci Bioeng 96:92–94, 2003; Appl Microbiol Biotechnol 72:173–181, 2006) have been reported.

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Amino-Acid Homopolymers Occurring in Nature by Munenori Takehara, Hideo Hirohara (auth.), Yoshimitsu Hamano (eds.)


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