By Lesley-Ann Giddings, David J. Newman
A dialogue of the chemicals produced via organisms dwelling lower than severe stipulations which can have strength as medications or results in novel medicines for human use. This SpringerBrief bargains with bioactive fabrics from terrestrial extremophiles.
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Extra resources for Bioactive Compounds from Terrestrial Extremophiles
Thus, the isolation of new pharmacophores from natural sources could possibly serve as leads to generate synthetic analogs with improved bioactivity. 7), a synthetic constituent of cigarette smoke that had previously never been isolated from a natural source (Dietera et al. 2003). Pyrocoll 100 was isolated from the alkaliphilic Streptomyces sp. AK409 obtained from steel waste tip soil. Interestingly, pyrocoll 100 exhibited antimicrobial activity against Arthrobacter strains (MIC, 1–10 µg/ml) and yeast, such as Rhodococcus erythropolis DSM 1069 (MIC, 10 µg/ml).
Interestingly, these pigments were not produced under low salt conditions (Banciu et al. 2005). No bioactivity has been reported for either of these compounds. Although Table 4 summarizes the bioactive agents discussed in this chapter as well as their sources and optimal pH required for growth, this list will significantly grow in time, as increased screening efforts over the past decade have demonstrated that researchers have underestimated the potential of alkaliphiles to produce pharmaceutical leads.
3 Berkeleyacetals A–C Three bioactive monoterpenes, berkeleyacetals A–C (73–75), were later isolated from P. 5) (Stierle et al. 2007). These monoterpenes possess a rare 6–7 A–B ring system containing an epoxide (berkeleyacetals B and C 74–75), methyl ester (berkeleycetals A and B 73–74), and/or ketone (berkeleyacetal C 75) functionality. The berkeleyacetal skeleton is most likely biosynthetically related to that of berkeleydione 67 via the alkylation of the polyketide intermediate 3,5-dimethylorsellinate by farnesyl pyrophosphate.
Bioactive Compounds from Terrestrial Extremophiles by Lesley-Ann Giddings, David J. Newman