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By Anna Nicolaou and George Kokotos

ISBN-10: 0953194973

ISBN-13: 9780953194971

Lipids are crucial parts of the mobile membrane proven to play many dynamic roles in mediating and controlling a big selection of mobile actions together with membrane constitution and association, metabolic and gene legislation, protein constitution and serve as, power creation and signalling pathways. the most target of this publication is to provide a transparent assessment of bioactive lipids to scientists and technologists now not absolutely conversant in lipid study. Chapters talk about the nomenclature, buildings, biochemistry, pharmacology and up to date advancements more often than not sessions of bioactive lipids. the 1st bankruptcy bargains with the homes and actions of fatty acids, via unique discussions of diacylglycerols, phosphoinositides and lysolipids. chapters conceal ceramides and glycosphingolipids. the rest reports prostanoids, leukotrienes and lipoxins, endocannabinoids and isoprostanes.

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Lipids are crucial parts of the telephone membrane proven to play many dynamic roles in mediating and controlling a big selection of mobile actions together with membrane constitution and association, metabolic and gene rules, protein constitution and serve as, strength construction and signalling pathways.

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In contrast, PGI3 is as active as PGI2 in inhibiting platelet aggregation and vasodilation (British Nutrition Foundation, 1992). , 2000). , 2002). Different isomers of CLA may have different effects on arachidonic acid metabolism. A dietary study reported that feeding a mixture of CLA isomers to rats resulted in decreased production of PGE2 by stimulated bone cultures ex vivo (Li and Watkins, 1998). Whether this effect is due to direct inhibition of arachidonic acid metabolism by CLA or to some other mechanism is not clear at this stage.

There are several types of lipoprotein. These differ in their ratio of lipid to protein; their proportions of triacylglycerol, esterified and non-esterified cholesterol, and phospholipids; and their metabolic functions (Table 2). These compositional differences influence the density of the particles, and it is therefore convenient to use density to separate and isolate lipoproteins by ultracentrifugation, and to classify plasma lipoproteins into different density classes: chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high density lipoproteins (HDL).

This contrasts with palmitic acid, which is attached to the protein post-translationally via an ester (usually thioester) linkage; palmitic acid can turn over much faster than the protein to which it is attached. Myristic and palmitic acids are attached to very distinct classes of proteins, including protein kinases, receptors, G-proteins and a number of oncogene products. These proteins appear targeted or anchored to specific regions of the plasma membrane, termed ‘rafts’ (Brown and London, 1998; Simons and Toomre, 2000; Pike, 2003).

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Bioactive lipids by Anna Nicolaou and George Kokotos


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