By V. P. Butler Jr. (auth.), Priv.-Doz. Dr. med. Günter Bodem, Prof. Dr. med. Hans J. Dengler (eds.)
In spite of previous classic and two hundred years of scientific use, digitalis is still an engaging healing agent, to clinicians in addition to to the pharmacologist, the biochemist, and co-workers in different diciplines of theoretic medication. whilst a drug, besides the fact that, has such a lot of beautiful elements, it kind of feels right and aJvis capable for the luck of a systematic assembly to target a few well-defined facets. This symposium was once dedicated to pharmacokinetics, drug metabolism, analytic systems, blood point determinations, and their interpretation either for thera peutic and poisonous events. substantial development has been made over the last years during this quarter of digitalis learn. The time used to be compatible for a severe achieve praisal of proof and theories and for destiny making plans. Our major goal used to be to narrate analytic facts and biochemical findings to scientific difficulties and questions. regardless of the unquestionably simple personality of scientific pharmacology, it's neverthe much less an utilized technology which can assist to enhance the rational foundation of thera peutics. we're fairly thankful to the lively members who bore the weight of getting ready displays and - even worse - manuscripts. even as we're well-aware that many different lively learn teams might were capable of give a contribution during this method, yet our application was once constrained as a result little while to be had. Their wisdom is incorporated within the dialogue components of the assembly, so we are hoping a well-balanced description of the current scenario emerged during this volume.
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47 In: Drug Metabolism in Man. Sci. : The pharmacokinetics and metabolism of digitoxin in man. In: Symposium on Digitalis. : The role of the liver in the chemical transformation of digitoxin. In: Symposium on Digitalis. ) Oslo: Gyldendal Norsk Forlag 1973 b, p. : Double isotope dilution derivative assay of digitoxin, digoxin, and their genins. In: Symposium on Digitalis. ) Oslo: Gyldendal Norsk Forlag 1973 c, p. : Determination of digitoxin in plasma by double isotope dilution derivative assay.
Of the body pool of digoxin 23%-56% was excreted as chemically intact digoxin, and the rest appeared to have been metabolized. 3). 6). As in the case of the 43 500 50 op· 24 F • PLASMA (OJ URINE FECES o )... 25 MG/DAY 001 Fig. 3. 5 mg of digoxin was discontinued. The ordinate is logarithmic. 5. 6. Cumulative excretion of digoxin and acid-hydrolyzable derivatives of Digoxigenin after stopping daily administration of drug Subject P V Urine (nmol) Feces (nmol) Total (nmol) % of body pool Digoxin Genin Digoxin Genin 394 35 429 23 364 36 400 21 389 86 475 56 361 86 447 53 steady-state studies, all of the digoxigenin was excreted in the form of digoxin; thus, there was no evidence of excretion of other digitoxosides or acid-labile derivatives of digoxigenin.
Louis, Missouri). 0 before incubation with a few drops of acetic acid if necessary. After incubation, one-half of the sample was analyzed for digoxin. 0 with hydrochloric acid, allowed to stand at room temperature for 18 h, and analyzed for digoxigenin and 3-epidigoxigenin that were released by the sequential anzymic and acid hydrolyses. 25-mg tablet form (Lanoxin, Burroughs Wellcome). Each subject had received the drug for at least the previous 6 months because of manifestations of left ventricular dysfunction due to myocardopathy in subject V, ischemic heart disease in Y, and hyperkinemia in P.
Cardiac Glycosides by V. P. Butler Jr. (auth.), Priv.-Doz. Dr. med. Günter Bodem, Prof. Dr. med. Hans J. Dengler (eds.)