By Eugene C. Toy
EXCEL on your neurology clerkship and at the USMLE Step 2 CK "This ebook is awesome. The medical circumstances are enticing and relaxing to learn, maximizing the absorption of necessary scientific info. i like to recommend this ebook to all scientific scholars on medical rotations."--Lance E. Davis, clinical pupil, UT Southwestern clinical tuition you wish publicity to circumstances to cross the USMLE and shelf assessments and that is precisely what this cutting edge source deals. Written through skilled educators, Case records: Neurology is helping you think that via analysis and managemenet while confronting neurological medical difficulties. fifty three high-yield scientific instances concentrate on the center knowledge for the neurology clerkship. each one case contains a longer dialogue, definitions of keyword phrases, medical pearls, and USMLE-format evaluate questions. it truly is an interactive studying process that is helping you study rather than simply memorize. that includes: fifty three neurology circumstances with entire discussions and overview Q&A medical pearls spotlight key issues Primer on find out how to strategy the sufferer is helping you examine within the context of actual sufferers
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Extra resources for Case Files: Neurology (Lange Case Files Series)
However, there is a large phenotypic variability even within families with an identical mutation. Primary generalized torsion dystonia is a progressive, disabling disorder that usually begins in childhood and is linked to several genetic loci. Many cases are inherited as autosomal 34 CASE FILES: NEUROLOGY dominant traits caused by a deletion in the torsin A gene (DYT1 locus), resulting in the deletion of glutamate in torsin A, a brain protein of unknown function with highest concentrations in the substantia nigra.
Primary dystonias are further subdivided by criteria such as age of onset, distribution of affected body parts, presence of diurnal variation of symptoms, responsiveness to drugs, and genetic markers. Secondary dystonia refers to dystonia in the context of a neurologic disease in which dystonia is only one of several symptoms or in which dystonia is the result of an environmental insult. There are at least 15 genetic causes of dystonia. Generalized dystonia tends to have its onset in childhood.
There is a large differential diagnosis for chorea including other inherited conditions, autoimmune, metabolic, and drug or toxin induced. (Table 2–1), but in the context of an adult with insidious onset and slow progression over several years, the likelihood is that this is a degenerative disease. Another form of chorea is Sydenham chorea, which is an acute, usually self-limited disorder of early life, usually between ages 5 and 15, or during pregnancy, and closely linked with rheumatic fever.
Case Files: Neurology (Lange Case Files Series) by Eugene C. Toy